objective(s) celecoxib acts through both cox-2-dependent and -independent pathways. according to the paradoxical effect of no on the inflammatory and nociceptive signal processing, the present study designed to evaluate the probable contribution of no in the analgesic and anti-inflammatory properties of celecoxib. materials and methods different intensities of inflammatory pain were induced by ...

introduction: dark neurons which their morphological characteristics are consistent with those of cells undergoing apoptosis, are generated as an acute or delayed consequence of several pathological situations. the present study was designed to evaluate whether inflammatory pain regarding the role of no and jnk lead to the formation of dark neurons in the dorsal horn of the lumbar spinal cord i...

introduction : post endodontic pain is often linked to the inflammatory process as well as additional central mechanisms. the purpose of the present double-blind randomized clinical trial study was to compare the prophylactic effects of a derivative of zingiber officinale , zintoma , and ibuprofen on post endodontic pain of molars with irreversible pulpitis. materials and methods: the post endo...

background most patients with trauma experience different levels of pain. due to side effects as well as economic burden of drugs used for pain relief after trauma commonly, it is important to use low-cost methods independently or combined with drugs to alleviate pain. objectives therefore, this study aimed to investigate the effects of topical sesame oil on pain severity and frequency of recei...

introduction: mineral trioxide aggregate (mta) is an endodontic material with different clinical applications e.g. root-end filling, pulp capping and perforation repair.  it has been reported to possess antimicrobial and antifungal activities. the aim of this study was to examine the effect of white mta on formalin-induced hyperalgesia in a rat with inflammatory pain. materials and methods: inf...

objective(s):based on the previous reports, silymarin can suppress nitric oxide, prostaglandin e2 (pge2), leukotrienes, cytokines production, and neutrophils infiltration. regarding the fact that inflammation plays an important role in neuropathic and formalin-induced pain, it was assumed that silymarin could reduce pain. the present study investigates the analgesic effects of silymarin in chem...

background: ghrelin is a peptide with attenuating effect on inflammatory pain. both anti- and pro-inflammatory mediators have a role in the nociception and development of pain and hyperalgesia. il-10 and tgf-β are anti-inflammatory cytokines and inhibit the expression of pro-inflammatory cytokines related to peripheral and central inflammatory pain. in this study, the effects of i.p. injection ...

context inflammatory pains caused by direct stimulation of nociceptors are altered by release of inflammatory mediators, cytokines and chemokines and also gut microbiota. a substantial clinical evidence supports the pivotal role of probiotics in the betterment of inflammatory disorders symptoms such as pain. therefore, this study aimed to review the potential anti-inflammatory and analgesic rol...

Background: Ghrelin is a peptide with attenuating effect on inflammatory pain. Both anti- and pro-inflammatory mediators have a role in the nociception and development of pain and hyperalgesia. IL-10 and TGF-β are anti-inflammatory cytokines and inhibit the expression of pro-inflammatory cytokines related to peripheral and central inflammatory pain. In this study, the effects of i.p. injec...

objective: pain control in dentistry especially endodontics is particularly important. endodontic pain following root canal therapy (rct) of vital teeth is closely correlated with inflammatory reactions. increased level of prostaglandins has been reported in acute inflammatory reactions. thus, cyclooxygenase-inhibiting drugs have a significant effect on reducing pain and inflammation. cox enzym...